Endocrine Abstracts

Introduction: Type 2 diabetes mellitus is a known complication of childhood obesity. It is currently diagnosed by undertaking an oral glucose tolerance test (OGTT). Continuous glucose monitoring (CGM) is used predominantly by patients with type 1 diabetes mellitus to monitor glucose levels.Aim: The aim of the study was to investigate glycaemic variation in children and adolescents with obesity who have had no evidence of pre-diabetes or type 2 diabetes o...

Introduction: Childhood obesity is associated with various complications and medical treatment options are limited. Liraglutide, a GLP-1 receptor agonist, has shown improvement in body mass index (BMI) in clinical trials and has been licensed for clinical use in adolescents >12 years of age. The aim of our study is to evaluate the effect of liraglutide treatment on cardiometabolic variables, quality-of-life (QoL) and satiety levels in adolescents with seve...

Introduction: Childhood obesity is associated with complications, such as impaired glucose tolerance and type 2 diabetes mellitus. The gold standard investigation for diagnosing glycaemic alterations is an oral glucose tolerance test (OGTT). Continuous glucose monitors (CGM) are routinely used in the management of children and young people (CYP) with type 1 diabetes mellitus. The aim of our study is to investigate whether CGM is more effective in identifying g...

Introduction: Obesity is a chronic and complex disease which is considered as one of the major health challenges with short- and long-term health consequences. Childhood obesity is defined as having a body mass index (BMI) at or above the 95th percentile for age and gender after two years of age. The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, is proven to promote weight reduction when used at a higher dose of 3.0 mg once daily. This study a...

Introduction: Evaluating hunger and hyperphagia is an important component of assessing children and young people with obesity. Identifying increased hunger levels will help clinicians and health professionals to taper management aspects including relevant genetic testing and providing tailored dietary and pharmacological management.Aim: The aim of this study was to evaluate the baseline hunger levels in a group of UK adolescents with severe obesity.<...

Introduction: Visceral body fat has been shown to correlate with complications related to obesity. Body mass index (BMI) is widely used to define obesity in the adolescent population; however, it does not take the overall body composition into account. We present body composition data in a group of UK adolescents attending the tertiary MDT weight management service.Methods: Data was collected on 31 patients (M:F = 15:16) attending the MDT service over a ...

Introduction: Childhood obesity is associated with several complications related to physical and mental health. Determining health-related quality of life (HRQOL) is an important outcome measure to ensure patients receive the appropriate care.Aim: We report the baseline HRQOL in a group of UK children and adolescents with severe obesity who were managed in a Tier 3 weight management service.Methods: Paediatric quality of life (Peds...

Background: Pubertal progression is inhibited in central precocious puberty with the use of gonadotropin releasing hormone (GnRH) analogues. They are usually given every 10 to 12 weeks via an intramuscular depot, but more recently, a 6-monthly preparation has become available for clinical use.Aim: The aim of this project was to evaluate the efficacy and acceptability of 6-monthly triptorelin, a GnRH analogue, at a tertiary children’s hospital.<p...

Background: Children and young people living with severe obesity experience wide ranging complications of excess weight (CEW), however their prevalence is not well defined. We have evaluated baseline clinical characteristics and complications in two multi-disciplinary tier-3 paediatric weight management services in different regions of the UK.Methods: All new patients (n=185) aged 2–17 years seen in a 12-mo...

Introduction: NCMP (National Childhood Measurement Programme) data has highlighted a higher prevalence of childhood obesity in highly deprived areas, however the prevalence of complications from excess weight (CEW) in relation to social deprivation has not been previously reported. The aim of this study is to compare the demographic data along with CEW in children and young people (CYP) with obesity being managed at two different centres in the UK, with a very...